| Regulation arranged by enzyme |
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| Enzyme |
Glucose-6-Phosphatase |
Fructose Bisphosphatase |
Pyruvate Carboxylase |
PEP Carboxykinase |
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| Abbreviation |
G6Ptase |
FBPtase |
Pyr Carbox |
PEP Carbox |
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| Hormonal (low
glucose) |
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| Hormonal (high
glucose) |
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| Energy |
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AMP (-) |
ADP (-) |
ADP (-) |
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| Feedback
inhibition |
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F2,6BP (-) |
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| Feedforward
activation |
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Citrate (+) |
Acetyl-CoA (+) |
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| Other
regulation |
high Km for G6P |
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| Comments |
Liver, not muscle or
brain |
(F1,6 Bisphosphatase) |
(also Anapleurotic) |
(also Anapleurotic) |
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| Regulation
arranged by molecule |
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| Molecule |
Glucose-6-phosphate |
Fructose-2,6-bisphosphate |
Citrate |
ADP |
AMP |
Acetyl-CoA |
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| Abbreviation |
G6P |
F2,6BP |
Citrate |
ADP |
AMP |
Acetyl-CoA |
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| Enzyme(s) |
G6Ptase |
FBPtase |
FBPtase |
Pyr Carbox, PEP Carbox |
FBPtase |
Pyr Carbox |
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| Pathway or
process indicator |
Glycolysis |
Glycolysis |
Citric acid cycle |
Energy |
Energy |
CAC |
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| Type of
regulation |
Km |
Feedback inhibition |
Feedforward |
Energy |
Energy |
Feedforward |
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| Comments |
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Also inhibits PFK
(glycolysis) |
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Also stimulates
Acetyl CoA Carbox (FA syn) |
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